
Are you looking for a delicious seafood dish that comes together quickly but tastes like you spent hours in the kitchen? This shrimp casserole recipe is exactly what you need! Tender shrimp coated in a creamy sauce, topped with a perfect blend of cheeses and crispy panko breadcrumbs – it’s the ultimate comfort food that my whole family devours.
I first made this casserole when I was in a dinner rut, and my husband David couldn’t stop raving about it. Even my kids Sophia and James, who can be particular about seafood, cleaned their plates and asked for seconds! That’s when I knew this recipe was a keeper that I had to share with you. If you enjoy seafood dishes like my Honey Garlic Salmon Bites, you’ll absolutely love this shrimp casserole.
Why You’ll Love This Shrimp Casserole
Simple Ingredients – Uses easy-to-find ingredients you might already have in your kitchen.
Quick Preparation – Ready in under 30 minutes with minimal hands-on time, perfect for busy weeknights.
Family-Approved – The cheesy, crispy topping makes this dish a hit even with kids who might be hesitant about seafood.

Ingredients for Shrimp Casserole
Shrimp – Use large shrimp (21-24 count) for the best texture in this casserole. Fresh or frozen work equally well, just make sure they’re peeled and deveined to save prep time.
Old Bay Seasoning – This classic seafood seasoning adds that distinctive flavor that makes this dish special. If you don’t have it, you can substitute with a mix of paprika, cayenne, and celery salt.
Mayonnaise – Creates the creamy base for the casserole. Use full-fat mayo for the richest flavor, though light mayo works in a pinch.
Garlic Powder – Adds depth without the harsh bite of fresh garlic. You can substitute 1-2 minced garlic cloves if you prefer.
Cheese Blend – The combination of mozzarella and medium cheddar creates the perfect balance of meltiness and flavor. Feel free to substitute with other melting cheeses like Monterey Jack or Colby.
Panko Breadcrumbs – Creates that irresistible crispy topping. Regular breadcrumbs work too, but panko gives the best texture.
How to Make Shrimp Casserole
Preheat your oven to 375°F. Grease a 2½ quart casserole dish or skillet with butter.

Prepare the shrimp. Bring a large pot of water to a boil and add 1 Tbsp salt and 1 Tbsp Old Bay Seasoning. Add the shrimp and cook for just 30 seconds until they’re opaque and cooked through. Immediately remove them with a strainer and transfer to a large mixing bowl.
Cool and drain the shrimp. Let them cool for a few minutes, then drain any water that collects at the bottom of the bowl, or use a paper towel to soak up any liquid.
Create the creamy mixture. Add mayonnaise, garlic powder, and black pepper to the shrimp and stir to coat evenly. The mayo creates a rich, flavorful base that will keep the shrimp moist during baking.

Add the cheese. Sprinkle the mozzarella and cheddar over the shrimp mixture and stir to combine everything well.
Transfer to baking dish. Spread the shrimp mixture evenly in your prepared casserole dish.

Prepare the topping. In a separate bowl, melt 1 Tbsp butter and stir in the panko breadcrumbs until they’re evenly moistened. Sprinkle this over the shrimp mixture.
Bake the casserole. Cook uncovered at 375°F for 13-15 minutes, or until the center reaches 145°F on an instant-read thermometer.
Broil for perfection. Turn on the broiler for 1-2 minutes to beautifully brown the breadcrumb topping.
Rest before serving. Let the casserole rest for about 15 minutes before serving. This helps the flavors meld together.
Variations of This Tasty Shrimp Casserole
Add vegetables – Mix in sautéed bell peppers, spinach, or mushrooms for extra nutrition and flavor.
Try different cheeses – Substitute Gruyère, Pepper Jack, or Parmesan for unique flavor profiles.
Spice it up – Add a dash of cayenne pepper or crushed red pepper flakes if your family enjoys heat.
Make it gluten-free – Use gluten-free panko or crushed pork rinds for the topping.
Add pasta – Mix in 2 cups of cooked penne or rotini pasta for a heartier one-dish meal that my kids absolutely love.
What to Serve with Shrimp Casserole
This versatile dish pairs beautifully with so many sides! Here are some suggestions:
- Roasted Baby Carrots with Honey for a sweet contrast
- A simple green salad with lemon vinaigrette
- Steamed rice or pasta to soak up the delicious sauce
- Cheesy Garlic Baked Green Beans for a complete meal
- Crusty bread for dipping into that creamy sauce

FAQs
A good casserole typically includes a protein (shrimp in this recipe), a binding ingredient (mayonnaise here), seasonings (Old Bay, garlic powder), and a topping (panko breadcrumbs and cheese). These elements create a delicious, cohesive dish that bakes perfectly together.
Bake this shrimp casserole uncovered at 375°F for 13-15 minutes, then broil for 1-2 minutes to brown the breadcrumbs on top. Baking uncovered allows the topping to get crispy and golden.
Old Bay Seasoning is the key flavor enhancer in this recipe, along with garlic powder and black pepper. Cooking the shrimp briefly in seasoned water before mixing with other ingredients ensures they absorb maximum flavor.
Bad shrimp will have a strong ammonia-like smell, slimy texture, or discoloration. Fresh shrimp should have a mild ocean scent, firm texture, and consistent pink/white coloring when cooked. Always check before using in your casserole.
More Seafood Recipes You’ll Love
- Air Fryer Shrimp – Another quick and delicious shrimp preparation
- Garlic Shrimp Gratin Recipe – If you love this casserole, try this similar dish with a French twist
- Air Fryer Salmon Bites – For another easy seafood dinner option
The Perfect Shrimp Casserole For any Occasion
Whether you’re serving this shrimp casserole for a weeknight family dinner or bringing it to a potluck, it’s sure to be a hit. The combination of tender shrimp, creamy sauce, and crunchy topping is simply irresistible!
I love how this dish comes together so quickly but tastes like something from a fine restaurant. My family asks for it regularly, and I don’t mind because it’s just so easy to prepare. The best part is watching everyone’s faces light up when I bring it to the table – even my kids give it two thumbs up!
Have you tried making this shrimp casserole? I’d love to hear how it turned out for you! Drop me a comment below with your experience or any variations you tried.
Happy cooking!


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Easy Shrimp Casserole Recipe
- Total Time: 25 minutes
- Yield: 4 servings 1x
Description
A comforting, cheesy, and creamy shrimp casserole that’s easy to prepare and guaranteed to be a family favorite—even the kids will ask for seconds!
Ingredients
- 1½ pounds large shrimp (21–24 count), peeled and deveined
- 1 tablespoon salt
- 1 tablespoon Old Bay Seasoning
- ¾ cup mayonnaise (preferably full-fat)
- ½ teaspoon garlic powder
- ½ teaspoon black pepper
- 1 cup shredded mozzarella cheese
- 1 cup shredded medium cheddar cheese
- 1 tablespoon butter (melted)
- ½ cup panko breadcrumbs
Instructions
- Preheat oven to 375°F. Grease a 2½ quart casserole dish or oven-safe skillet with butter.
- Bring a large pot of water to a boil. Add salt and Old Bay Seasoning. Add shrimp and cook for 30 seconds until opaque. Remove and transfer to a large mixing bowl.
- Let shrimp cool slightly, then drain any liquid or pat dry with paper towels.
- Mix in mayonnaise, garlic powder, and black pepper until shrimp are evenly coated.
- Add shredded mozzarella and cheddar, stir to combine well.
- Spread shrimp mixture evenly in the prepared casserole dish.
- In a separate bowl, combine melted butter and panko breadcrumbs. Stir to moisten and sprinkle over the shrimp mixture.
- Bake uncovered at 375°F for 13–15 minutes, or until the internal temperature reaches 145°F.
- Turn on broiler for 1–2 minutes to brown the topping.
- Let the casserole rest for 15 minutes before serving.
Notes
Don’t overcook shrimp in the boiling step—they only need 30 seconds. Make ahead by prepping through step 7 and refrigerating for up to 3 days. Add a tablespoon of lemon juice or sprinkle with fresh parsley for extra flavor.
- Prep Time: 10 minutes
- Cook Time: 15 minutes
- Category: Main Course
- Method: Baked
- Cuisine: American
Nutrition
- Serving Size: 1 serving
- Calories: 480
- Sugar: 2g
- Sodium: 860mg
- Fat: 34g
- Saturated Fat: 11g
- Unsaturated Fat: 19g
- Trans Fat: 0g
- Carbohydrates: 9g
- Fiber: 1g
- Protein: 35g
- Cholesterol: 220mg